Gliseraldehid 3-fosfat dehidrogenase
Gliseraldehid 3-fosfat dehidrogenase

Gliseraldehid 3-fosfat dehidrogenase

1U8F, 1ZNQ, 3GPD, 4WNC, 4WNI2597100042025ENSG00000111640tiadadataP04406P16858NM_001357943
NM_001357944XM_001476707NP_001243728
NP_001276674
NP_001276675
NP_002037
NP_001344872NP_001276655
NP_032110Gliseraldehid 3-fosfat dehidrogenase (disingkat GAPDH) (EC 1.2.1.12) ialah enzim dengan berat kira-kira 37 kDa yang memangkinkan langkah keenam glikolisis, dan dengan itu, berfungsi untuk memecahkan glukosa untuk menghasilkan tenaga dan molekul karbon. Sebagai tambahan kepada fungsi metabolisme yang telah lama diketahui, GAPDH baru-baru ini diketahui terlibat dalam beberapa proses bukan metabolisme, termasuk pengaktifan transkripsi, permulaan apoptosis,[4] pengulangalikan vesikel ER-Golgi dan pengangkutan aksoplasma.[5] Dalam sperma, GAPDHS isoenzim khusus testis dinyatakan.

Gliseraldehid 3-fosfat dehidrogenase

Struktur-struktur sedia adaPDBSenarai kod-kod PDB
Struktur-struktur sedia ada
PDBPencarian ortolog: PDBe RCSB
Senarai kod-kod PDB

1U8F, 1ZNQ, 3GPD, 4WNC, 4WNI
Senarai kod-kod PDB
Senarai kod-kod PDB

1U8F, 1ZNQ, 3GPD, 4WNC, 4WNI
JalurMula 12p13.31
Corak ekspresi RNABgeeHumanMouse (ortholog)BioGPS
Corak ekspresi RNA
Bgee
HumanMouse (ortholog)
Top expressed in
  • frontal pole

  • Pons

  • Brodmann area 10

  • triceps brachii muscle

  • deltoid muscle

  • Brodmann area 46

  • body of tongue

  • middle frontal gyrus

  • postcentral gyrus

  • tibialis anterior muscle
    tiada data
More reference expression data
BioGPS
tiada data
UniProt

P04406
Spesies Manusia
Kedudukan gen (Manusia)Kr.JalurMulaTamat
Kedudukan gen (Manusia)
Kr.Kromosom 12[1]
Jalur12p13.31Mula6,534,512 bp[1]
Tamat6,538,374 bp[1]
Kr. Kromosom 12[1]
OrtologSpesiesEntrezEnsemblUniProtRefSeq (mRNA)NM_002046NM_001256799NM_001289745NM_001289746NM_001357938RefSeq (protein)Kedudukan (UCSC)Carian PubMed
Ortolog
SpesiesManusiaMencit
Entrez

2597

100042025

Ensembl

ENSG00000111640

tiadadata

UniProt

P04406

P16858

RefSeq (mRNA)
NM_002046
NM_001256799
NM_001289745
NM_001289746
NM_001357938

NM_001357943
NM_001357944

XM_001476707

RefSeq (protein)

NP_001243728
NP_001276674
NP_001276675
NP_002037
NP_001344872

NP_001276655
NP_032110

Kedudukan (UCSC)Chr 12: 6.53 – 6.54 Mbtiada data
Carian PubMed[2][3]
RefSeq (mRNA)NM_002046NM_001256799NM_001289745NM_001289746NM_001357938
NM_002046
NM_001256799
NM_001289745
NM_001289746
NM_001357938

NM_001357943
NM_001357944
Carian PubMed [2]
RefSeq (protein)

NP_001243728
NP_001276674
NP_001276675
NP_002037
NP_001344872
Pengecam-pengecam luaran OMIM: 138400 MGI: 5434255 HomoloGene: 107053 GeneCards: GAPDH
PDB Pencarian ortolog: PDBe RCSB
Kedudukan (UCSC) Chr 12: 6.53 – 6.54 Mb
Alias GAPDH, GAPD, G3PD, HEL-S-162eP, glyceraldehyde-3-phosphate dehydrogenase
Ontologi gen
Ontologi gen
Fungsi molekul
Komponen sel
Proses biologi
Sumber:Amigo / QuickGO
BioGPS
tiada data
BgeeHumanMouse (ortholog)
HumanMouse (ortholog)
Top expressed in
  • frontal pole

  • Pons

  • Brodmann area 10

  • triceps brachii muscle

  • deltoid muscle

  • Brodmann area 46

  • body of tongue

  • middle frontal gyrus

  • postcentral gyrus

  • tibialis anterior muscle
    tiada data
More reference expression data
Ensembl

ENSG00000111640
Tamat 6,538,374 bp[1]
Entrez

2597

Rujukan

WikiPedia: Gliseraldehid 3-fosfat dehidrogenase http://enzyme.expasy.org/EC/1.2.1.12 https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P04406 https://doi.org/10.1038%2Fsj.onc.1210074 https://doi.org/10.1016%2Fj.cell.2012.12.029 https://doi.org/10.1016%2Fj.cellsig.2010.08.003 https://doi.org/10.1111%2Fj.1440-1681.2011.05599.x https://doi.org/10.1016%2Fj.abb.2011.11.020 https://doi.org/10.1099%2Fmic.0.048298-0 https://doi.org/10.1016%2Fj.vetmic.2004.05.008 https://doi.org/10.1128%2FIAI.74.1.382-389.2006